LPL and obesity due to melanocortin 4 receptor deficiency: Although there is limited evidence concerning the effect of interaction of fat intake with genes on metabolic disease risk in the SA population, interestingly, high intake of SFA (>23 g/day) was reported to interact with 3SNP-GRS (CETP rs4783961 and LPL rs327, rs3200218), increasing obesity risk in Indians.61