Obesity is an inflammatory and hypercoagulant state (Malandish and Gulati 2023) characterized by chronically elevated thrombin levels (Chitongo et al. 2017, Bertaggia Calderara et al. 2020) and an overactive NLRP3 inflammasome (Bauer et al. 2023, Cho et al. 2023). Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.