TARDBP and amyotrophic lateral sclerosis: Indeed, FOXO inhibition induces overall locomotor and survival benefits in fruit flies with specific muscle knockdown of TBPH and caz. Actually, the four different Drosophila ALS models used in this study reproduce some ALS outcomes, such as shortened lifespan and impaired neuromuscular function, as described for TDP-43 knockdown in Drosophila [76].