TARDBP and amyotrophic lateral sclerosis: Accordingly, a previous study reported that TDP-43 forms physiological cytoplasm granules in murine C2C12 myotubes at late stages of differentiation, which are critical for regulating sarcomeric protein translation and myotube maturation in mice [81] cytoplasmic TDP-43 protein granules in myoblasts from either ALS patients or control subjects.