The observation of the involvement of gastric acid secretion pathway, LINC02864, MAGEA family proteins, LTF, and KLK10 with HCMV infection will guide future studies to explore the previously undermined involvement of HCMV in the GC pathogenesis and early identification of high-risk GC patients based on the presence of HCMV infection. The gene discussed is KLK10; the disease is gastric cancer.