The latest version of chronic hepatitis B (CHB) treatment guidelines or guidelines [1–3] issued by the American Association for the Study of Liver Diseases (AASLD), European Association for the Study of the Liver (EASL) and Asian-Pacific Association for the Study of the Liver(APASL), according to alanine aminotransferase(ALT), HBV-DNA and hepatitis B e antigen, CHB is divided into four phases: (1) immune tolerance phase, (2) immune active phase or immune clearance phase, (3) inactive phase or low replication phase, (4) reactivity period. Here, GPT is linked to liver disorder.