F10 and Cognitive impairment: Recent randomized-controlled trials (RCTs) showed positive effects in certain acute surgical and medical management for ICH (e.g. intensive care bundle with blood pressure reduction, early minimal invasive hematoma evacuation, and the use of andexanet alfa in factor Xa inhibitors associated ICH), resulting in better functional outcome, reduced mortality, and reduced hematoma volume.77 Since poststroke cognitive impairment correlates with size of hematoma, it is likely that these treatments will result in less cognitive impairment post-ICH.