Additionally, studies have revealed the impact of the CXCL13/CXCR5 axis on the homing and angiogenesis of EPCs in the progression of rheumatoid arthritis (RA), particularly highlighting the role of CXCL12 in EPCs, especially in promoting angiogenesis and the migration of EPCs in inflammatory environments [33]. This evidence concerns the gene CXCR5 and rheumatoid arthritis.