High abundance of Desulfovibrio and low abundance of Clostridia ultimately lead to a decrease in the expression of CD36 (Buttet et al., 2014), a key regulator of lipid absorption in the intestinal tract, and its deficiency leads to lipid metabolism disorders and excessive accumulation of adipocytes in the body (Buttet et al., 2016), which in turn increases the chances of obesity and metabolic syndrome caused by HFD feeding (Ma et al., 2022). This evidence concerns the gene CD36 and obesity due to melanocortin 4 receptor deficiency.