This is consistent with the findings of Yu Baowen et al. It was proposed that Cer(d18:1/24:1) levels are increased in the metabolic profile of obese subjects, which leads to reduced insulin sensitivity and is associated with metabolic disturbances in obesity and may also contribute to obesity comorbidities (Yu et al., 2023). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.