M. oleifera fruits extract contains flavonoids as antioxidants.2,35 The antioxidant activity of flavonoids comes from their ability to donate hydrogen atoms and the ability to chelate metal.18M. oleifera fruits extract was also anti-obesity because it can down-regulate leptin and resistin mRNA expression while at the same time up-regulating the expression of adiponectin mRNA.8 Vitamin C as an antioxidant agent given as a positive control in group P3 can be compared withM. oleifera fruits extract. Here, RETN is linked to obesity due to melanocortin 4 receptor deficiency.