LEP and obesity due to melanocortin 4 receptor deficiency: Epidemiological studies show that obesity was associated with an increased risk of cancer.16,18 One of the cancers thought to occur due to obesity was hepatocellular carcinoma.13,17,19 Obesity causes dysregulation of growth signals such as increased insulin and leptin.20–22 Obesity causes angiogenesis, tumorigenesis and chronic inflammation.15,23 Experts suspect obesity is also associated with the incidence of hepatocellular cancer.15,24,25 The chemical 2-Nitropropane can induce hepatocellular.26 2-Nitropropane (2NP) can trigger the mechanism of hepatocarcinogenesis.17,24,27