CLOCK and cancer: For example, knock out of the core clock geneBMAL1 in mouse models of solid tumors promotes tumor progression in CRC (Chun, Fortin, Fellowset al., 2022;Stokeset al., 2021), lung (Papagiannakopouloset al., 2016), and other cancer types (Leeet al., 2010) but reduces the development of cutaneous squamous tumors (Janichet al., 2011).