APC and colorectal carcinoma: Due to its important role in the destruction complex,APC mutation results in aberrant activation of the Wnt signaling pathway (Korinek, 1997;Morin, 1997;Moseret al., 1990).APC mutations are sufficient to drive CRC initiation of adenoma growth (Cheunget al., 2010;Lamlumet al., 2000;Rowanet al., 2000;Zauberet al., 2016;Zhang & Shay, 2017).