Apcex1-15/Bmal1-/- mice developed more intestinal polyps thanApcex1-15 mice. Organoids fromApcex1-15/Bmal1-/- mice transformed into tumor spheroids due toApc LOH. Circadian rhythms were lost in human colorectal tumors versus normal surrounding epithelial. The gene discussed is BMAL1; the disease is colorectal neoplasm.