Integrin ανβ3 is expressed on EC and several malignancies, such as melanoma, glioma, ovarian and breast cancer, and mediates cancer cell adhesion to EC and also interaction with both VWF and platelets (Felding-Habermann et al., 1996; Bombeli et al., 1998; Felding-Habermann et al., 2001; Pilch et al., 2002; Terraube et al., 2006). This evidence concerns the gene VWF and central nervous system cancer.