Platelet integrin αIIbβ3, also known as the glycoprotein GPIIb/IIIa, is capable of interacting with VWF, cancer cells and EC to facilitate cancer cell adhesion to platelets and EC (Felding-Habermann et al., 1996; Bombeli et al., 1998; McCarty et al., 2000). Here, VWF is linked to cancer.