VWF and cancer: Besides these established roles of VWF in hemostasis and thrombosis, high VWF levels in cancer patients have been linked to tumor metastasis (Gadducci et al., 1994; Zietek et al., 1996; Eppert et al., 2005; Wang et al., 2005; Boccaccio and Medico, 2006; Terraube et al., 2007; Liu et al., 2014).