Access to HIF target genes within these regions is aided by proteins like Chromodomain-helicase-DNA-binding protein 4 (CHD4); a protein that is increasingly implicated in promoting stemness and chemoresistance in breast cancer (Novillo et al., 2021; Zhang J. et al., 2022; D’Alesio et al., 2019; Wang Y. et al., 2020). The gene discussed is CHD4; the disease is breast cancer.