ESR1 and breast cancer: Interestingly, a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits has been investigated in prostate cancer models and ERα positive ZR-75-1 breast cancer cells, which showed FOXA1-driven cancer cells to be significantly sensitive to SWI/SNF attenuation (Xiao et al., 2022).