Oestradiol further upregulates levels of glycolytic intermediates as well as those of enzymes belonging to the pentose phosphate pathway, such as glucose-6-phosphate dehydrogenase (G6PD), potentially linked to mTORC1 over-activation; mTORC1 then promotes anaerobic glycolysis, cancer growth and metastasis (Sun et al., 2014). This evidence concerns the gene G6PD and cancer.