CXCL8 and neoplasm: As a result of both the increased expression of HIF-1α-regulated genes and increased IL-8 we see promotion of tumour formation and growth by enhancing vascularisation, as well as by regulating hormone receptor signalling (Waugh and Wilson, 2008).This fine tuning of gene expression via transcription factor activation and epigenetic remodelling, highlights the vast impact of hypoxia on cellular physiology.