AKT1 and neoplasm: In tumour cells glucose-based energy production is regulated by epigenetic mediators, such as long non-coding RNAs (lncRNAs), either directly by controlling the levels of glycolytic enzymes or glucose transporters (e.g., hexokinase 2, lactate dehydrogenase A (LDHA), pyruvate kinase isoenzyme M2, and pyruvate dehydrogenase kinase 1), or indirectly by interfering with signalling pathways such as PI3K/PKB, AKT/mTOR and Wnt/Snail (Lin, 2020; Tan et al., 2021).