Survival and migration of triple negative breast cancer cell lines, as well as their expression of the voltage-gated sodium channel Nav1.5 has been linked with expression of the α subunit of HIF1 (HIF-1α), with both HIF-1α and Nav1.5 being upregulated in the more aggressive TNBC cell lines, compared to other breast tumour subtypes (Dewadas et al., 2019). This evidence concerns the gene SCN5A and breast neoplasm.