POU5F1 and breast carcinoma: Another Ca2+ sensor of particular importance for breast cancer is the HIF-1α-induced S100A10 protein, which forms a complex with the autophagy related annexin A2 protein, the histone chaperone SPT6 and the demethylase KDM6A, mediating H3K27me3 demethylation at the site of the pluripotency regulatory gene OCT4, and thus promoting breast cancer stemness (Lu et al., 2020).