STAT3 and cancer: In TNBC, depletion of GPX8 has been shown to reduce EMT, induce loss of cancer stemness and decreased tumour growth, observations which were explained through a reduction in the interleukin 6 (IL-6) signalling via the Janus Kinase (JAK)/Signal Transducers and Activators of Transcription 3 (STAT3) pathway, with IL-6 being a known initiator of EMT (Khatib et al., 2020; Bharti et al., 2016).