Thus, feeding a small amount of bile acids with minimal enteral feeding is a frequent clinical practice in PN-fed infants to treat cholestasis with mixed results 41, 42, yet the most common bile acid used is ursodeoxycholic acid, which is not an FXR agonist and has been shown to exert FXR antagonistic effects 43. The gene discussed is NR1H4; the disease is cholestasis.