Evidence suggests that intestinal epithelial cells express receptors that recognize FGF19, such as FGFR4 and β-Klotho, and cultured mouse enteroids respond to FGF19 treatment 38 and inhibition of FGF19 reduced growth and metastasis of colon tumor grafts 39, 40. The gene discussed is FGFR4; the disease is colonic neoplasm.