To find genes that altered the viability of VHL-null cells, we employed the widely-used ccRCC models 786O and RCC4 alongside paired VHL-reconstituted lines (786O+VHL and RCC4+VHL) (Fig. 1a and Extended Data Fig. 1a)12,35,36. This evidence concerns the gene SLC49A4 and nonpapillary renal cell carcinoma.