CD274 and neoplasm: Moreover, the non-long-strand coding RNA lncRNA MX1-215 can directly interact with the H3K27 acetylase GCN5, interrupting the combination of GCN5 and H3K27, interfering the transcription of PD-L1 and LGALS9 mediated by the acetylation of H3K27, and decreasing the acetylation level and expression level of PD-L1 and galectin-9 on the tumor cells [32].