TP53 and lung adenocarcinoma: Through the functional enrichment analysis of miRNA target genes, it was found that the target genes were significantly enriched in negative regulation of apoptosis, RNA binding, gene expression, mRNA monitoring pathway, transcriptional imbalance in cancer and TGF-β, P53 signaling pathway, etc. Among them, most pathways have been supported to be closely related to the mechanism of tumorigenesis, such as TGF-β signal pathway mediates EMT of lung adenocarcinoma cells and promotes the migration and invasion of lung adenocarcinoma cells [39].