NOTCH1 and melanoma: It has been demonstrated that TN potently inhibited melanoma cell and gastric cancer cell growth and metastasis via induction of SAV1 (salvador family WW domain-containing protein 1)/LATS1 (large tumor suppressor kinase 1) expression and activation of Hippo pathway [31] or via inhibition of the oncogenic Notch1 and NF-κB signaling pathways [28].