White et al. (2022) have observed that cigarette smoke intensifies Pseudomonas aeruginosa-induced mitophagy, resulting in an accumulation of p62, exacerbation of mitochondrial damage, and heightened activation of NLRP3 inflammasome in alveolar macrophages, which ultimately aggravates Pseudomonas aeruginosa-induced ALI. This evidence concerns the gene NLRP3 and acute respiratory distress syndrome.