While this PINK1-mediated mitophagy is documented to suppress NLRP3 inflammasome activation in acute liver ischemia-reperfusion injury, its role in regulating NLRP3 in the context of ALI, though unreported, is presumed to be of significant therapeutic relevance (Shan et al., 2019). The gene discussed is NLRP3; the disease is acute respiratory distress syndrome.