Under high oxygen conditions, the expression of BMI1 (B cell-specific Moloney murine leukemia virus integration site 1) significantly decreases, resulting in loss of Δφ, increased expression of PTEN (phosphatase and tensin homolog) and Pink1, enhanced mitophagy, and cell death in alveolar epithelial cells, exacerbating ALI. The gene discussed is PINK1; the disease is acute respiratory distress syndrome.