TPM1 is only one of the many sarcomeric genes that have been linked to DCM; mutations in proteins such as titin, TnC, TnI, TnT, myosin, and actin have also been implicated (Carballo et al., 2009; Huang et al., 2015; Landim-Vieira et al., 2020; Song et al., 2010; Du et al., 2007; Sun et al., 2012; Hinson et al., 2015; Hershberger et al., 2013; Gomes and Potter, 2004; Tadros et al., 2020). Here, TTN is linked to familial dilated cardiomyopathy.