TNF and obesity due to melanocortin 4 receptor deficiency: Examination of the fibroinflammatory effects of obesity in MMP14LKO mice revealed that both WD and HFFC feeding in mice increased hepatic inflammatory marker gene expression—TNFα, CXCL2, CXCL9, TGFβ, and IL-1β—in WT mice, and this was attenuated in WD-fed MMP14LKO mice (Fig. 4A–F).