Cui et al. showed that downregulation of m6A writers METTL3/METTL14 or m6A erasers ALKBH5/FTO reduces m6A on oncogenic ADAM19 mRNA, increasing its expression and driving self-renewal of glioblastoma stem cell, leading to aggressive tumor behavior and metastasis [29]. The gene discussed is ALKBH5; the disease is glioblastoma.