Since the fourth study [29] evaluated a motor, social, exploratory, and anxiety-like behavior in the shank3Δex4−22 mouse at earlier developmental timepoints (2–8 weeks), the current study may combine with the work of Contestabile et al., to provide a more comprehensive understanding of how behavioral domains are affected by the loss of all SHANK3 isoforms over time. This evidence concerns the gene SHANK3 and Anxiety.