NFE2L2 and obesity due to melanocortin 4 receptor deficiency: Quercetin, also a flavonoid, inhibits TNF-α-induced atrophy factors such as the expression of muscle ring finger 1 and muscle atrophy F-box in myotubes and increases nuclear translocation of NRF2 with inactivation of NF-κB while enhancing HO-1 protein levels to prevent muscle atrophy under obesity conditions.109