STIM1 and neoplasm: Our previous studies revealed that STIM1 promotes the growth of HCC in a hypoxic environment, accelerates metabolic reprogramming in HCC, leading to enhanced invasion and metastasis, and enhances self-renewal of liver cancer stem cells.9, 10, 11 Furthermore, studies have demonstrated that STIM1 inhibits apoptosis in most tumors, except prostate cancer12,13 and promotes autophagy in certain tumor types.14