From the perspective of osteoimmunology, the detailed global profile of BM cells was delineated at the single-cell level, and the evidence of osteoclast inhibition was further clarified, which including a dysregulated cytokine network leading to decreased osteoclastogenesis and osteoclastic differentiation and identification of Cd36+ cells (MM2) in vivo in the T2D environment. The gene discussed is CD36; the disease is type 2 diabetes mellitus.