Moreover, increased STING expression and IRF3 phosphorylation were further elevated by inhibiting Parkin-mediated mitophagy in the hearts of TAC mice (Fig. 6H–J), as well as the increase in the transcription of IFN-β and ISGs activated by the STING pathway (Fig. 6K–M). This evidence concerns the gene IRF3 and persistent truncus arteriosus.