Consistently, STING deficiency significantly restored the cardiac pump function (Fig. 1C–E), and mitigated cardiac hypertrophy and interstitial fibrosis, as evidenced by reduced heart weight-to-tibia length ratio (Fig. 2E), cardiomyocyte cross-sectional area and fibrosis area (Fig. 2F–H). The gene discussed is STING1; the disease is cardiac hypertrophy.