This study did not explore the relationship among TSGF, CD105-MVD, and cervical cancer staging, but the efficacy difference between MRI diagnosis and MRI combined with HE4, TSGF, and CD105 diagnosis of advanced cervical cancer was compared, and it was found that the combined diagnosis had an accuracy rate of 96.0% (96/100), AUC (95% CI) = 0.960 (0.908–1.000), which confirmed that combining the four presented an ideal diagnostic efficacy. The gene discussed is ENG; the disease is cervical cancer.