In the multivariable linear mixed effects model with log of ANA titer as the outcome (Table 4), at time of first positive ANA test, the average titer strengths (log units) for both the other rheumatic disease and SLE groups were significantly higher compared to the ANA+ controls [coefficients 0.33 (95% CI 0.26, 0.39) and 0.42 (95% CI 0.36, 0.48), respectively; p < 0.001 for both], controlling for age, gender, race, and ethnicity. This evidence concerns the gene BTG3 and systemic lupus erythematosus.