Following positive preclinical results, 68Ga-labeled Nb APN09 entered a phase I clinical trial (NCT05156515), where PET/CT imaging with [68Ga]Ga-THP-APN09 in nine NSCLC patients showed a positive correlation between PD-L1 expression and tracer accumulation in tumors [64]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.