IFIH1 and dermatomyositis: Furthermore, the anti-MDA5 autoantibody is detected in 20-50% of adult DM patients (including CADM) and is associated with relatively lower creatine kinase (CK) levels, a high frequency of ILD (90-95%), especially rapidly progressive ILD (RP-ILD) (50-80%), and poor prognosis due to respiratory failure (62–65).