The results demonstrated that CKAP4, BCL6 and TLR8 levels were significantly upregulated in ICH patients compared with those in IS patients, HTN controls and CTRLs but were not significantly different between IS patients and HTN controls (or CTRLs) in both the discovery (Figures 6A-C) and validation cohorts (Figures 6D-F). This evidence concerns the gene CKAP4 and hypertensive disorder.