Proinflammatory cytokines, including interleukin 6 (IL-6), interleukin 12 (IL-12), and interleukin 1 beta (IL-1β) upregulate inflammatory cytokine responses to limit infection, while anti-inflammatory cytokines such as IL-10 can inhibit expression of proinflammatory cytokines to down regulate the inflammation process (21). Here, IL1B is linked to infection.