Proinflammatory cytokines, including interleukin 6 (IL-6), interleukin 12 (IL-12), and interleukin 1 beta (IL-1β) upregulate inflammatory cytokine responses to limit infection, while anti-inflammatory cytokines such as IL-10 can inhibit expression of proinflammatory cytokines to down regulate the inflammation process (21). The gene discussed is IL6; the disease is infection.