Additionally, the most activated TFs in each subgroup within the M1-M5 modules were identified as follows: MAF in the C0 IGLL5+ Myeloma Cells subgroup, LEF1 in the C1 IGHG4+ Myeloma Cells subgroup, TCF12 in the C2 MALAT1+ Myeloma Cells subgroup, and CREB5 in the C3 IGHG1+ Myeloma Cells subgroup. This evidence concerns the gene IGHG1 and plasma cell myeloma.