Such survival benefits of NSAIDs have been shown 2% - 12% decrease in patients with severe sepsis with low-dose Aspirin (100 mg per day) treated and pre-treated (32–34), but not for patients older than 70-year (35), which was achieved through the anti-inflammatory lipoxin and NF-κB pathways due to its non-specific COX inhibitory activity and antiplatelet properties (36, 37). The gene discussed is NFKB1; the disease is Sepsis.