Meloxicam treatment in low IL-6 responders septic mice decreased PLF PGE2 (119.22-fold, adj.P=0.01) levels compared to Non-A sepsis groups, while circulating PGE2 increased in the Metamizole treated low IL-6 responders septic group compared to Meloxicam-treated mice (1.11-fold, adj.P=0.017) (Figures 5A, B, Supplementary Figure 4). Here, IL6 is linked to Sepsis.