The common incidence of grade 3-4 AEs and all grade AEs included abdominal pain, decreased appetite, hypertension, nausea, diarrhea, rash, hand-foot syndrome, elevated aspartate aminotransferase (AST), elevated alanine aminotransferase (ALT), thrombocytopenia, thyroid dysfunction (Table 3). This evidence concerns the gene GPT and Hand-foot syndrome.