PRF1 and colorectal carcinoma: Comparing between MSS and MSI-H CRC, they found that a subset of γδ TILs with high cytotoxicity (characterized by expression of PRF1, GZMA, CCL5, ENO1, PKM and GNLY) was enriched in mismatch repair (MMR)-deficient CRC, whereas the less cytotoxic, PLZF+ wound-healing γδ TIL subset (with high expression of ZBTB16, AREG, TAGLN2 and CD44) was associated with MMR-proficient CRC (26).