Additionally, immune associated terms such as TNF,IL17, B cell, T cell and Th1 signalling pathways were also enriched, This again validates in in silico, the potential role of the T2DM-OA-TNBC interactome in disease initiation, and carcinogenesis in particular, converging on metabolic, immune and cancer associated pathways. The gene discussed is TNF; the disease is type 2 diabetes mellitus.