Furthermore, considering the obvious role of CXCL9 chemokine as the most powerful contributor to age-related chronic inflammation (iAge) and cardiac and vascular dysfunction, and its possible role in the pathogenesis of CVD events in RA patients, in our previous study we measured the plasma level of CXCL9 and gene expression of CXCR3 in RA and control groups and at the following, in this study, we also evaluate the association between CXCL9/CXCR3 axis with LncRNA-HIX003209 and miR-6089 gene expression in the newly-diagnosed and under-treatment RA patients peripheral blood [36,38]. Here, CXCR3 is linked to rheumatoid arthritis.