Also, recently we provided evidence that CXCL9 chemokine and its receptor CXCR3, which induces infiltration of TH1 and MQ to the inflammatory sites, have correlated with different variables of traditional CVD risk factors and cardiac biomarkers including NT-proBNP and HS-CRP in RA patients and may be considered inflammatory factors that contributes to the pathogenesis of CVD in RA patients [36,37]. The gene discussed is NPPB; the disease is rheumatoid arthritis.