TLR4 exerts a pivotal role in the inflammatory pathway through activation of NF-κB, the critical inflammatory transcription factor, which induces the expression of different genes encoding for proinflammatory cytokines, including TNF-α, IL-6, which collectively play an indispensable role in RA pathogenesis [26,27]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.