Previous documents showed that miR-6089 was significantly decreased in the serum exosome of patients with RA compared to healthy individuals, and on the other hand, with increased over-expression of miR-6089 followed by targeted control of TLR4 signaling, the production of IL-6, IL-29 and TNF-α cytokines decreases [49]. This evidence concerns the gene TLR4 and rheumatoid arthritis.