These authors also showed how the chemokine CXCL12 could induce FAK and pFAKY397 upregulation in MCL cell lines; in particular, as CXCL12 is highly expressed in MSCs from MCL bone marrow (BM-MSCs), the co-culture between stromal cells and MCL cell lines, or primary MCL cells, identified an upregulation of the FAK signaling pathway, such as AKT, ERK1/2, and NF-kB. The gene discussed is PTK2; the disease is mantle cell lymphoma.