RUNX1 and acute myeloid leukemia: FAK gene expression can, in fact, be negatively regulated by two miRNAs (i.e., hsa-let7a-2-3p and hsa-miR-135a-5p), which are in turn regulated by RUNX-1 (runt-related transcription factor 1), which is often mutated in the high-risk AML subset.