Furthermore, VS-4718 (0.1–1 μM) combined with the BCL-2 (B-cell lymphoma 2 protein) inhibitor venetoclax (13–200 nM) had a synergistic effect in inducing the apoptosis of AML cell lines, even in co-culture conditions with mesenchymal stromal cells (MSCs), which mimic the pro-survival support from the tumor microenvironment (37–39). Here, BCL2 is linked to acute myeloid leukemia.