Helicobacter pylori is a major risk factor for gastric cancer, and through GIT organoid studies Buti et al. (2020) found that apoptosis-stimulating protein of p53 2 (ASPP2), a tumor suppressor and important target of CagA, contributes to the survival of CagA-positive H. pylori in the lumen of infected gastric organoid tissues and that it is a key protein in disrupting cell polarity. Here, TP53BP2 is linked to gastric cancer.