Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptides and hyperphosphorylated tau (p-Tau) protein in senile plaques and neurofibrillary tangles, respectively, which cause neurotoxicity and neuron loss, leading to memory and learning impairments (Silva et al., 2019). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.