FFAR2 and Hepatic fibrosis: Studies have shown that disorders of intestinal flora can accelerate liver fibrosis (Le Roy et al., 2013; Hu et al., 2021; Awoniyi et al., 2023), while microbial SCFAs are shown to induce the apoptosis of various cells through G protein-coupled receptors (GRP41 and GRP43, also known as free fatty acid receptors FFAR3 and FFAR2) (Kimura et al., 2001; Shi et al., 2014), suggesting that SCFAs potentially accelerate liver fibrosis by exacerbating hepatocyte apoptosis, which deserves further investigation.