These components, widely used in health foods and supplements with minimal toxicity, target core proteins (NFKB1, ALB, AKT1, ACTB, TNF, IL6, ESR1, CASP3, and PTGS) to modulate cancer, lipid and atherosclerosis, human cytomegalovirus infection, and the PI3K-Akt signaling pathway. This evidence concerns the gene ESR1 and cytomegalovirus infection.