Gestational Diabetes Mellitus (GDM) is a condition in which intolerance develops to glucose at first in gestation and remains in the later trimesters.1 During pregnancy the glucose uptake reduces by 40-60% along with marked insulin resistance i.e. three times compared to a non-pregnant state.2,3 To compensate for this, blood insulin is increased up to twice the normal levels, and if β-cells of Langerhans (pancreas) are unable to secrete the required insulin to encounter that raised glucose then GDM develops.4 The rate of GDM varies globally due to different diagnostic criteria. The gene discussed is INS; the disease is gestational diabetes.