MYH14 and peripheral arterial disease: Diabetes-related vascular complications, i.e. Peripheral arterial disease (PAD) commonly affects the lower extremity (Aortoiliac to pedal arteries) than the upper extremity vasculature.7 PAD’s pathogenesis is a vicious cycle that has an atherosclerotic (clot/ thrombus) obstruction-induced blood flow restriction which results in ischemia and endothelial dysfunction that causes skeletal muscle fiber denervation, atrophy, and altered myosin expression, ultimately alters aerobic muscle metabolism.