Therefore, EGFR-TKI can also downregulate VEGF, while VEGF inhibitors can inhibit HER-1/EGFR signaling.10 Therefore, it is possible that EGFR-TKI combined with VEGF may not only inhibit cell proliferation and promote cell apoptosis, but also reduce tumor neovascularization and delay the development of the EGFR-TKI resistance. Here, EGFR is linked to neoplasm.