TNF and pancreatitis: The abnormal production of cytokines and inflammatory mediators such as TNF-α, WBC, IL-6, CRP in pancreatitis is caused by excessive activation of nuclear transcription factor NF -κβ pathway and toll pathway that trigger the cascade amplification reaction, potentially leading to multiple organ dysfunction and failure.19,20 Xu et al.21 showed that in patients with acute pancreatitis, Ulinastatin combined with Somatostatin can reduce inflammatory reaction and enhance immune function.