TNF and acute pancreatitis: Ulinastatin and Somatostatin are commonly used in the treatment of acute pancreatitis.6,7 Somatostatin is a protease inhibitor that suppresses the production of digestive enzymes, reduces the secretion of gastrin and insulin, induces apoptosis of pancreatic acinar cells, and prevents gastrointestinal injury caused by trypsin.7 Ulinastatin is a glycoprotein, which can reduce the absorption of toxin, inhibit the production of tumor necrosis factor, improve the stability of vascular endothelial cells, reduce the activity of trypsin, and reduce myocarditis and myocardial injury.6-8