To date, over 10 pathogenic genes associated with CSA have been reported, including ALAS2, SLC25A38, GLRX5, HSPA9, HSCB, ABCB7, PUS1, YARS2, LARS2, TRNT1, MT-ATP6, NDUFB11, and SLC19A2 (4–7). Here, ALAS2 is linked to chromosome-type aberration frequency.