Patients with advanced cancer also suffer from a sense of fatigue and malaise, called cancer-related fatigue (CRF).2 A meta-analysis reported that 60.9% of patients with advanced cancer were experiencing CRF,3 which is associated with both patients’ quality of life and daily activities.4 CRF is caused by several factors, including tumor growth, pain, anemia, poor nutrition, deconditioning, depression, and cancer therapy.5 Inflammatory cytokines (IL-6, TGF-β)6 and an increased level of oxidative stress7 are also known to cause CRF. Here, IL6 is linked to cancer.