Of the 508 patients with glioma, the expression of PCDH18 (p < 0.001), DEPP1 (p < 0.001), VASN (p < 0.001), KCNE4 (p < 0.01), MYBPH (p < 0.001) and MARCH4 (p < 0.01) genes was significantly different between G2 and G3. This evidence concerns the gene PCDH18 and central nervous system cancer.