Multivariate Cox regression analysis showed that the expression of PCDH18 (p < 0.05), PPL (p < 0.05), DEPP1 (p < 0.01), VASN (p < 0.001), KCNE4 (p < 0.001), MYBPH (p < 0.001), C5AR2 (p < 0.001), and MARCH4 (p < 0.001) was an independent predictor of glioma which is most closely related to the survival of patients with glioma, independent of other variables, and has significant prognostic value (Figure 8). Here, KCNE4 is linked to central nervous system cancer.