FLT1 and central nervous system cancer: The majority of the antineoplastic activity of honeybee venom has been attributed to melittin through inhibition of VEGF, FLT-1, and MMP-9 in glioma C6 cells [31]; metaloprotease-2 in human glioblastoma cells [32]; and STAT3 and VEGF in glioma SHG44 cell [33].